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目前国外普遍用抗癫(疒间)大发作持续状态(下文称SE)药物的药代动力学知识来指导此类药物在临床实践中的应用,为临床合理用药提出了理论根据,并在实践中收到了良好效果。临床上首选快速类抗SE药以尽快控制SE,然后再用长效抗SE药维持疗效的方法已得到公认。对于难控制的SE病人,可试用丙戊酸钠、利多卡因和Clometiazole。关于抗SE药与血清中蛋白结合的能力,以及抗(疒间)药之间或抗(疒间)药与其它药物之间的相互作用影响该药物原有疗效的问题,也受到了广泛注意。
At present, foreign countries generally use the pharmacokinetic knowledge of the sustained-onset antiepileptic drug (SE) to instruct the application of such drugs in clinical practice, and put forward the theoretical basis for the rational use of drugs in clinical practice Received good results. The preferred method of clinically preferred fast-acting anti-SE agents for controlling SE as soon as possible and then using long-acting anti-SE agents to maintain efficacy has been well established. For patients with refractory SE, try sodium valproate, lidocaine, and Clometiazole. Concerns about the ability of anti-SE drugs to bind to proteins in serum, as well as the interaction between anti-tuberculosis drugs or anti-tuberculosis drugs and other drugs have affected the original curative effect of this drug and received extensive attention.