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用离子选择性电极测定药物,研究甚多,其中大都是生物碱、季铵等类碱性药物,与非水滴定等法相比、优点并不显著,至于抗生素类药物,常用微生物法分析,缺点很多,本文报告土霉素的阳离子型与阴离子型电极,探讨了选择性规律,电极在pH1.6～3.2与pH8.0～11.0分别响应含质子化二甲胺基的土霉素一价阳离子与含离解B环烯醇基的土霉素一价阴离子,1gK_(ij)与季铵离子势及诱导效应指数有良好的线性关系,符合1gK_(ij)=a+bI-cZ/R,极限值7.07。
Ion-selective electrode for the determination of drugs, many studies, most of them alkaloids, quaternary ammonium and other basic drugs, and non-aqueous titration compared to the law, the advantages are not significant, as antibiotics, common microbial analysis, shortcomings Many, this article reports oxytetracycline cationic and anionic electrodes to explore the selectivity of the electrode at pH1.6 ~ 3.2 and pH8.0 ~ 11.0, respectively, in response to protonated dimethylamino-containing oxytetracycline monovalent cation The results showed that there was a good linear relationship between 1gK_ (ij) and quaternary ammonium ion potential and induced effect index, which was consistent with 1gK_ (ij) = a + bI-cZ / R, Value of 7.07.