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目的分析头孢菌素类药物联合其他药物致不良反应情况及相应的处理措施。方法 226例需使用头孢菌素类药物及其他药物患者,对其临床资料进行统计,分析患者出现药品不良反应原因,比较联合用药前后不良反应的发生率。结果联合用药后患者不良反应明显多于联合用药前(P<0.05);联合用药后,肾功能损害患者8例,消化系统不良反应患者15例,神经系统不良反应患者10例,二重感染患者9例,过敏反应患者17例。结论在临床中进行头孢菌素药物及其他药物联合使用所致不良反应的研究对于提高药物使用安全性及有效性具有重要意义,用药过程中应做好预防工作,减少药品不良反应。
Objective To analyze the adverse reactions caused by cephalosporins combined with other drugs and the corresponding treatment measures. Methods A total of 226 patients with cephalosporins and other drugs were enrolled in this study. The clinical data were statistically analyzed to analyze the causes of adverse drug reactions in patients. The incidence of adverse reactions before and after combination therapy was compared. Results After treatment with combination therapy, the adverse reactions in patients were significantly more than those before combination therapy (P <0.05). After combination therapy, 8 patients with renal dysfunction, 15 patients with digestive system adverse reactions, 10 patients with nervous system adverse reactions, 9 cases, allergic reaction in 17 cases. Conclusions It is of great significance to study the adverse reactions caused by the combined use of cephalosporin and other drugs in clinic to improve the safety and effectiveness of drug use. Preventive work should be done in the course of medication to reduce the adverse reactions of drugs.