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目的 :探讨非小细胞肺癌 (NSCLC)患者血清MMP 2、MMP 9水平与肿瘤转移的关系。 方法 :采用抗人MMP 2、MMP 9单克隆抗体 ,用ELISA法检测 72例非小细胞肺癌患者及 2 0例健康志愿者血清MMP 2和MMP 9水平。 结果 :NSCLC患者血清MMP 2和MMP 9含量显著高于正常对照组。NSCLC有转移组血清MMP 2和MMP 9水平显著高于NSCLC无转移组。 结论 :血清MMP 2和MMP 9浓度可作为预测非小细胞肺癌转移的指标。
Objective: To investigate the relationship between serum MMP-2, MMP-9 and tumor metastasis in patients with non-small cell lung cancer (NSCLC). Methods : Serum levels of MMP 2 and MMP 9 in 72 NSCLC patients and 20 healthy volunteers were detected by ELISA using anti-human MMP 2 and MMP 9 monoclonal antibodies. Results : Serum MMP 2 and MMP 9 levels in NSCLC patients were significantly higher than those in normal controls. The levels of serum MMP 2 and MMP 9 in the NSCLC metastatic group were significantly higher than those in the NSCLC non-metastasis group. Conclusion : Serum MMP 2 and MMP 9 concentrations can be used as predictors of metastasis of NSCLC.