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我院1978年4月～1987年12月共收治结核病1642例,发现因使用类固醇激素(下称激素)而致结核病12例(初发10例,复发2例),占同期收治结核病的0.73%. 临床资料男4例,女8例,年龄16～63岁,平均46.9岁.激素所治疗的原发病包括类风湿性关节炎、风湿热、系统性红斑狼疮、支气管哮喘、慢性肝炎、病毒性脑炎等.激素用量折算为强的松15～90mg日,平均28mg.使用时间最短21天,最长12年,其中6例<3个月.长期用药者多系结缔组织病而反复不规则用激素治疗.12例结核病变主要累及肺部,其中浸润型8例,双肺结核者5例,有空洞4例,合并胸水2例及肠结核1例;粟粒型4例,其中合并结脑2例.本组11例作痰涂片和(或)培养检查.阳性7例(63.6%),脑脊液查见结核
In our hospital, from April 1978 to December 1987, a total of 1642 cases of tuberculosis were admitted and 12 cases of tuberculosis (10 cases initially treated and 2 cases relapsed) were found to be caused by the use of steroid hormone (hereinafter referred to as hormone), accounting for 0.73% Clinical data of 4 males and 8 females, aged 16 to 63 years, mean 46.9 years old.Hormone treatment of the primary disease, including rheumatoid arthritis, rheumatic fever, systemic lupus erythematosus, bronchial asthma, chronic hepatitis, virus Encephalitis, etc .. Hormone dosage converted to prednisone 15 ~ 90mg day, an average of 28mg. The shortest use of time 21 days, up to 12 years, of which 6 cases <3 months. The rules of hormone therapy .12 cases of tuberculosis mainly involving the lungs, including infiltration in 8 cases, 5 cases of tuberculosis in two, 4 cases of empty, pleural effusion in 2 cases and 1 case of intestinal tuberculosis; miliary type in 4 cases, 2 cases.The group of 11 cases of sputum smear and (or) culture examination positive in 7 cases (63.6%), cerebrospinal fluid check see tuberculosis