在試制“右旋糖酐注射液”时(Dextran solution)遇到了热原問題。採用活性炭吸除,效果不大;即使把活性炭的用量加到3%,仍未能使成品合格。后来考虑到溶液中热原含量与炭粉上吸附量一定处于某种平衡狀态。炭粉吸附热原的作用在某种程度上服从有机溶剂抽取水溶液中物質的分布定律(Low of partition)。根据这一推测,我們採用兩次分次吸除法,就是先加一半 The pyrogen problem was encountered during trial production of Dextran solution. Activated carbon removal, the effect is not; even if the amount of activated carbon added to 3%, still failed to make the finished product qualified. Later, taking into account the pyrogen content in solution and the amount of carbon adsorption must be at some equilibrium state. The role of charcoal to adsorb pyrogens to some extent obeys the Low of partition of substances in aqueous solutions extracted with organic solvents. According to this speculation, we use two sub-suction method, is to add half