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目的:观察黄芪皂苷注射液对实验性心衰犬心脏舒缩功能的影响。方法:采用中枢抑制药-戊巴比妥钠诱发麻醉犬在体急性心衰模型,iv黄芪皂苷注射液,同时测定左心室收缩压(LVSP)、左室舒张末压(LVEDP)、收缩压最大上升速率(+dp/dtmax)、舒张压最大下降速率(-dp/dtmax)及心率(HR)等心功能指标。结果:黄芪皂苷注射液能明显增加心衰犬LVSP、+dp/dtmax、-dp/dtmax,对LVEDP和HR无明显影响。结论:黄芪皂苷注射液具有增强心肌收缩力,改善心脏收缩和舒张功能,对急性心衰有明显的治疗作用。
Objective: To observe the effects of astragaloside injection on cardiac diastolic function in experimental heart failure dogs. METHODS: An acute anesthetic dog model of acute heart failure induced by pentobarbital sodium and iv astragaloside injection were used. Simultaneous determination of left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and maximum systolic blood pressure was performed. Rate of heart rate (+dp/dtmax), maximum diastolic pressure (-dp/dtmax), and heart rate (HR). RESULTS: Astragalus saponin injection could significantly increase LVSP, +dp/dtmax, and -dp/dtmax in heart failure dogs, without significant effects on LVEDP and HR. Conclusion: Astragalus saponin injection can enhance myocardial contractility, improve cardiac contractility and diastolic function, and have obvious therapeutic effect on acute heart failure.