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目的探讨限制性输液对失血性休克大鼠血流动力学的影响。方法制作大鼠失血性休克模型,采取限制性输液和大量输液两种不同输液方法复苏大鼠失血性休克,对比各组不同时间点的血流动力学变化,记录出血量、输液量并计算生存率。结果休克模型120 min后,与大量输液组比较,限制性输液组的呼吸、心率降低,有统计学意义,平均动脉压和中心静脉压明显升高(P<0.05);休克急救期,限制性输液组失血量少于大量输液组(P<0.05),输液量明显低于大量输液组(P<0.05);休克后24 h和72 h生存率比较,限制性输液组高于大量输液组(P<0.05)。结论限制性输液能明显改善失血性休克大鼠的血流动力学,减少失血量以及输液量,提高生存率,是复苏失血性休克的理想方法。
Objective To investigate the effects of restrictive infusion on hemodynamics in hemorrhagic shock rats. Methods The model of hemorrhagic shock in rats was established. Hemorrhagic shock was resuscitated in rats by two different infusion methods, including restrictive infusion and transfusion. The hemodynamic changes at different time points were compared, and the amount of blood transfusion and the amount of transfusion were calculated rate. Results After 120 min of shock model, the respiration and heart rate in the limited infusion group were significantly lower than those in the bulk infusion group (P <0.05). The mean duration of shock and rescue The transfusion group had less blood loss than the large transfusion group (P <0.05) and the transfusion volume was significantly lower than that of the large transfusion group (P <0.05). The survival rate at 24 h and 72 h after shock was higher in the transfusion group than in the transfusion group P <0.05). Conclusion Restrictive infusion can significantly improve hemodynamics, reduce blood loss and infusion volume and improve survival rate in hemorrhagic shock rats. It is an ideal method for resuscitation hemorrhagic shock.