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目的:观察消化膏湿热敷治疗粉刺性乳痈僵块期的疗效、安全性及对体液免疫功能、炎症的影响。方法:选取2018年1月至2019年1月间本院收治的85例粉刺性乳痈僵块期患者为研究对象，随机分为对照组(42例)和观察组(43例)，对照组口服托里消毒散、外用紫色消肿膏，观察组加用消化膏湿热敷，30 d为一疗程。比较两组临床疗效、症状积分、乳房肿块大小、体液免疫指标、CRP、血沉，记录不良反应。结果:治疗后两组免疫球蛋白、补体无明显改变(n P>0.05)，疼痛评分、乳房肿物大小、肿块评分，CRP、血沉均较治疗前显著降低(n P<0.05)；组间比较，观察组治疗后疼痛评分、乳房肿物大小、肿块评分，CRP、血沉均明显低于对照组(n P<0.05)。观察组总有效率为83.7%，明显高于对照组的59.5%(n P0.05), but the pain score, breast tumor size, mass score, CRP and ESR were significantly decreased than those before treatment (n P<0.05); compared with the control group, the pain score, breast tumor size and mass score in the observation group were significantly lower than those in the control group (n P<0.05). The total effective rate of the observation group was 83.7%, which was significantly higher than 59.5% of the control group (n P<0.05). There were no obvious adverse reactions in both groups.n Conclusions:Hot-wet compression with Xiaohua ointment is effective and safe for patients with acne mastitis in mass stage, and could improve their inflammation.