男,52岁。因无明显诱因出现失眠、兴奋、话语增多、吐他人口水、打人、乱砸东西10 d 收入某精神病医院。诊断为躁狂症。给予氟哌啶醇、卡马西平治疗1周,症状未见好转,仍兴奋、脾气暴躁、幻听、幻视及胃纳差、恶心。后发现病人夜尿增多,5次/夜,量少。查肾功能 Cr 719μmoL/L,BUN 48 Male, 52 years old. Because there is no obvious incentive insomnia, excitement, discourse, vomit his mouth water, beaten, chaos smashed something 10 d income of a psychiatric hospital. Diagnosed as mania. Given haloperidol, carbamazepine treatment for 1 week, the symptoms did not improve, still excited, irritable, auditory hallucination, hallucination and poor appetite, nausea. After the patient found nocturia, 5 times / night, less. Check renal function Cr 719μmoL / L, BUN48