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为了观察脑活素、胞二磷胆碱联合治疗新生儿缺氧缺血性脑病（ＨＩＥ）的近、远期疗效，寻求一种最佳治疗方案，对１９７例诊断为中、重度ＨＩＥ的患儿，随机分为治疗组，对照组Ⅰ、对照Ⅱ、对照Ⅲ共４组，采用不同的方法，均给予充分治疗。出院后分别在生后３、６、１２、１８、２４、３０、３６、４２个月定期进行智力及神经系统功能随访，进而相互对比研究。结果显示近期疗效不能完全反映ＨＩＥ患儿的真正预后，要通过近、远期随访，发现问题及时给予合理治疗，尽可能保证患儿神经系统功能的恢复。提示尽早联合用药、治疗合理、疗程足、多疗程则疗效更好
In order to observe the short-term and long-term curative effect of combined treatment of neomycin and citicoline on neonatal hypoxic-ischemic encephalopathy (HIE), one of the best treatment options for 197 cases diagnosed as moderate and severe HIE Children were randomly divided into treatment group, control group Ⅰ, control Ⅱ, control Ⅲ a total of 4 groups, using different methods were given adequate treatment. After discharge, 3, 12, 12, 18, 24, 30, 36 and 42 months after birth, intelligence and neurological function were regularly followed up and then compared with each other. The results show that the short-term efficacy can not fully reflect the true prognosis of children with HIE, to follow-up, long-term follow-up and found that the problem of timely and appropriate treatment, as far as possible to ensure the recovery of children with nervous system function. Prompt as soon as possible combination therapy, reasonable treatment, full course of treatment, more treatment is better