胎盘蛋白12(PP12)是从正常足月胎盘中分离出的几种蛋白中的一种。它是一个糖蛋白,含有4.3%的碳水化合物,其分子量从25,200～51,000。PP12的生物学作用尚未弄清。在胎儿和母亲血清中 PP12的浓度变动于40～460μg/1,而羊水中的浓度高100～500倍。PP12定位于胎盘的合体细胞滋养层和蜕膜中。本文报道,用免疫组织化学方法显示PP12是一种依赖于孕酮的蛋白质,着床前后它出现于内膜中。从106例因有异常妇科出血史而进行治疗的妇女获得内膜样品,其中有些曾用过激素取代治疗。将组织用缓冲液福尔马林固定,石蜡包埋,连续切 Placental protein 12 (PP12) is one of several proteins isolated from the normal term placenta. It is a glycoprotein containing 4.3% carbohydrates with molecular weights ranging from 25,200 to 51,000. The biological role of PP12 has not yet been clarified. PP12 concentrations in fetal and maternal serum ranged from 40 to 460 μg / l, whereas amniotic fluid concentrations were 100 to 500 fold higher. PP12 is located in the placenta syncytiotrophoblast and decidua. Here we report that by immunohistochemistry, PP12 is a progesterone-dependent protein that appears in the intima before and after implantation. Endometrial samples were obtained from 106 women who had had a history of abnormal gynecological bleeding, some of whom had been treated with hormone replacement therapy. The tissue was fixed with buffered formalin, embedded in paraffin and cut continuously