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目的：探讨DNA含量与AgNOR对甲状腺良恶性滤泡性肿瘤的鉴别诊断价值。方法：应用流式细胞术和胶体银染技术对9例正常甲状腺组织和36例滤泡性肿瘤（22例腺瘤和14例腺癌）进行DNA含量分析和AgNOR计数。结果：14例滤泡性癌中，11例为DNA异倍体，而22例滤泡性腺癌仅1例为DNA异倍体，且伴有不典型增生。AgNOR由正常甲状腺组织、滤泡性腺癌至滤泡性癌逐渐增加，相互之间有显著性差异（P＜0．05）；但各组间AgNOR计数有重叠，且DNA含量与AgNOR无明显相关性。结论：尽管AgNOR染色方法简便。经济，但在区别良恶性滤泡性肿瘤方面，DNA含量异常更具意义。
Objective: To investigate the value of DNA content and AgNOR in differential diagnosis of benign and malignant thyroid follicular neoplasms. METHODS: DNA content analysis and AgNOR count were performed on 9 normal thyroid tissues and 36 follicular tumors (22 adenomas and 14 adenocarcinomas) using flow cytometry and colloidal silver staining techniques. Results: Among 14 cases of follicular carcinoma, 11 cases were DNA aneuploids, and 22 cases of follicular adenocarcinoma were only 1 case of DNA aneuploidy with dysplasia. AgNOR was gradually increased from normal thyroid tissue, follicular adenocarcinoma to follicular carcinoma, and there was a significant difference between them (P<0.05). However, there was overlap in AgNOR count between groups, and there was no significant correlation between DNA content and AgNOR. Sex. Conclusion: Although the AgNOR staining method is simple. Economically, but in distinguishing between benign and malignant follicular tumors, abnormal DNA content is more meaningful.