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目的探讨心脏肌钙蛋白I(cTnI)与不稳定型心绞痛(UAP)临床分级的关系和对远期预后的判断价值。方法对119例UAP患者和148例健康对照者分别进行血清cTnI测定,并观察2年内心脏事件发生情况。结果UAP组血清cTnI≥016ngml的UAP患者2年内心脏事件发生率为480%,显著高于血清cTnI<016ngml患者的101%(P<0005),比数比(RR)=817,95%可信限为312～2134。cTnI≥016ngml预测UAP患者2年内发生心脏事件的灵敏度为774%,特异性为710%,阳性预测值480%,阴性预测值为90%。UAP组内随着Braunwald临床分级增高,Ⅰ～Ⅲ级血清cTnI值也相应增高,呈显著正相关关系(r=+07781,P<005)BraunwaldⅢ级患者中,血清cTnI升高者,2年心脏事件发生率为59%,显著高于BraunwaldⅢ级中血清cTnI正常的UAP患者的211%(P<005)。结论血清cTnI水平与UAPBraunwald临床分级呈显著的正相关关系并且对UAP患者2年预后有重要的判断价值。
Objective To investigate the relationship between cardiac troponin I (cTnI) and clinical classification of unstable angina pectoris (UAP) and to evaluate its long-term prognosis. Methods 119 cases of UAP patients and 148 healthy controls were measured serum cTnI, and observed 2-year incidence of cardiac events. Results The UAP group had a 2-year incidence of cardiac events of 480 MTT in UAP patients with serum cTnI≥016 ngml, significantly higher than 101% of patients with serum cTnI <016 ng ml (P <0005), and a RR of 817.95% The limit is 312 ~ 2134. cTnI ≥016 ngml The sensitivity, specificity, and sensitivity of 774%, 710%, 480%, and 90% of the predictive value of cardiac events within 2 years in patients with UAP. There was a significant positive correlation between the cTnI level and the cTnI level in the UAP group as Braunwald’s grade increased (r = +07781, P <005). Among Braunwald Ⅲ patients, elevated serum cTnI, 2-year heart The event rate was 59%, significantly higher than 211% of UAP patients with normal serum cTnI in the Braunwald class III (P <005). Conclusion Serum cTnI level has a significant positive correlation with UAPBraunwald clinical grade and has important judgment value for 2-year prognosis of UAP patients.