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从六十年代开始建立和发展起来的造血干细胞培养方法,为研究血细胞的起源、增殖、分化提供了实验手段。在囓齿类动物中已可测定多能干细胞,粒、红、巨核和淋巴系定向干细胞。人的粒、红、巨核系定向干细胞培养亦相继获得成功,并逐渐应用于临床,尤其在白血病、再生障碍性贫血(再障)和骨髓移植研究上。以下主要就近两年有关再障的造血干细胞培养情况作一简介。一、再障的造血干细胞及其它因素1.CFU-C(粒系定向干细胞)理论上讲人 CFU-C 也是从多能干细胞(CFU-S)分化而来,并经历着向形态上可辨认的粒系细胞进一步分化增殖过程的定向干
The methods of culturing hematopoietic stem cells that have been established and developed since the 1960s provide the experimental means for studying the origin, proliferation and differentiation of blood cells. Pluripotent stem cells, granulocytes, red, megakaryocytes, and lymphoid committed stem cells have been measured in rodents. Human granulocyte, red and megakaryocyte stem cell lines have also been successfully established and gradually applied to clinical practice, especially in leukemia, aplastic anemia (aplastic anemia) and bone marrow transplantation. The following mainly in the past two years on aplastic anemia of hematopoietic stem cell culture for a brief introduction. 1. Aplastic anemia hematopoietic stem cells and other factors 1. CFU-C (granulocyte-directed stem cells) Theoretically, human CFU-C is also differentiated from pluripotent stem cells (CFU-S) and undergoes morphological discernible Of granulosa cells further differentiate the process of proliferation of directional dry