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目的探讨兰索拉唑三联疗法在治疗上消化道溃疡的效果以及安全性.方法随机的将260例患者分为兰索拉唑治疗组和对照组各为130例,治疗组采用兰索拉唑30 mg+左氧氟沙星0.2 g+克拉霉素0.5 g 疗法来进行治疗,对照组采用法莫替丁20 mg+左氧氟沙星0.2 g+克拉霉素0.5 g 疗法来进行治疗,并将治疗的效果以及对 Hp 的根除情况进行比较.结果治疗组的总有效率及 Hp 根除率分别为95%和87%,明显的高于对照组的81%和68%,差异有统计学意义(P<0.05).结论兰索拉唑三联疗法对 Hp 根除率高,对上消化道溃疡具有较好疗效,值得临床推广.“,”Objective: To investigate the lansoprazole triple therapy in the treatment of upper digestive tract ulcer effect and safety. Methods: randomized 260 patients were divided into treatment group and control group of lansoprazole in 130 cases, treatment group with lansoprazole 30 mg+ 0.2 g+ 0.5 g levofloxacin triple to clarithromycin treatment, control group with famotidine 20 mg+ levofloxacin 0.2 g+ clarithromycin 0.5 triple g to the treatment, and the treatment effect as wel as on Hp eradication compared. Results: the total effective rate in treatment group and Hp eradication rates were 95% and 87%, significantly higher than that in the control group were 81% and 68%, the difference was statisticaly significant ( P<0.05 ). Conclusion: lansoprazole triple therapy for eradication of Hp rate is high, the ulcer of upper digestive tract with good effect, worthy of clinical application. [Key words] Upper gastrointestinal ulcers; Lansoprazole; Helicobacter pylori; Triple therapy