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目的综合评价孕妇血清微柱凝胶法检测IgG抗体效价与新生儿溶血病(HDN)的关系。方法利用Meta分析方法对53篇近期中外关于IgG抗体效价与新生儿溶血病(HDN)的关系的研究文献进行综合定量分析。结果共有15篇符合条件的文献纳入分析,Meta分析表明,当母亲血清中IgG抗A(B)效价≥64时,其血型不合胎儿发生ABO-HDN危险性的OR值为0.482;血清中IgG抗A(B)效价≥256时,发生ABO-HDN危险性的OR值为0.724。结论 1gG抗A(B)效价阳性率与HDN发病率相关;产前IgG抗A(B)效价越高,HDN发病率就越高,0型血孕妇应定期检测体内1gG抗A(B)效价水平,结果异常及时治疗。
Objective To evaluate the relationship between IgG antibody titers and neonatal hemolytic disease (HDN) in pregnant women by using microcolumn gel method. Methods Meta-analysis was used to analyze 53 recent articles on the relationship between IgG titer and neonatal hemolytic disease (HDN) in China and foreign countries. Results A total of 15 eligible articles were included in the analysis. Meta-analysis showed that the risk of ABO-HDN was 0.482 when the maternal serum IgG anti-A (B) titer was ≥ 64, and the serum IgG The OR for risk of developing ABO-HDN at anti-A (B) titer ≥256 was 0.724. Conclusion The positive rate of 1gG anti-A (B) titer is related to the incidence of HDN. The higher the prenatal IgG anti-A (B) titer is, the higher the incidence of HDN. Pregnant with type 0 blood should be tested regularly for 1gG anti-A ) Titer level, the results of abnormal treatment in time.