肌萎缩性侧索硬化症(ALS)在病因方面的研究,曾涉及多种因素如遗传、感染、营养障碍、外伤、中毒等,但仍不能阐明 ALS 的本质,近几年来在 ALS 的病因探索方面又有新的进展,现综述如下:一、遗传因素本病大多为散发性,少数有家族性,根据 Jokelainen 统计有家族史者为5～10％,但藤森等在日本长野县南部调查结果为27％。ALS 主要为常染色体显性遗传,也可 Amyotrophic lateral sclerosis (ALS) in the etiology of the study, has been involved in many factors such as genetic, infectious, nutritional disorders, trauma, poisoning, etc., but still can not clarify the essence of ALS in recent years the cause of ALS exploration There are new developments, are summarized as follows: First, the genetic factors Most of the disease is sporadic, a few have familial, according to Jokelainen statistics have a family history of 5 to 10%, but Fujimori and other southern Nagano Prefecture in Japan findings 27%. ALS is mainly autosomal dominant, but also