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为研究甲型肝炎减毒活疫苗（L－A－1株）口服免疫的免疫原性，114只小白鼠1次口服免疫后1～8周内，每周收集肠洗液和血清样品，用ELISA方法检测特异抗体反应。111只小白鼠检测到阳性抗体反应，阳转率为93．37％。肠洗液S－IgA阳转率高峰在第1和第6周（65％和64％）。血清IgA于第一周未测到，其高峰在第6周（100％）。IgM于第1周即达高峰（88％），IgG于第3周达高峰（88％）。至第8周末，S－IgA维持在40％，IgA、IgM和IgG分别维持在90％，80％和80％。实验结果表明，该疫苗口服免疫后具有良好的免疫原性，可激活小白鼠的局部与全身免疫反应。
To study the immunogenicity of oral immunization of live attenuated Hepatitis A vaccine (L-A-1 strain), enteric wash and serum samples were collected weekly for 1 to 8 weeks after 1 oral immunization of 114 white mice with ELISA method to detect specific antibody response. 111 mice detected positive antibody response, positive conversion rate was 93.37%. Enteropathic S-IgA positive rates peaked at weeks 1 and 6 (65% and 64%). Serum IgA was not detected in the first week, its peak in the first 6 weeks (100%). IgM peaked at week 1 (88%) and IgG peaked at week 3 (88%). By the end of the 8th week, S-IgA remained at 40%, with IgA, IgM and IgG maintained at 90%, 80% and 80%, respectively. The experimental results show that the vaccine has good immunogenicity after oral immunization and can activate the local and systemic immune responses in mice.