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目的:系统评价脂肪的摄入与子宫内膜癌发病风险间的相关性。方法 :采用计算机检索Pub Med、Web of science、EMbase、CBM、维普数据库、万方数据库,查找有关脂肪酸摄入与子宫内膜癌发病风险间相关性的流行病研究,文献检索时限至2016年6月止。所有文献均由2位研究者严格地按照纳入和排除标准筛选和提取,采用Stata11.0软件分别对总脂肪、饱和脂肪酸、多不饱和脂肪酸及单一不饱和脂肪酸进行荟萃分析。结果 :最终纳入16篇研究,共6 480个研究对象。结果显示,与低摄入量人群相比,高总脂肪[OR=1.22,95%CI为1.02~1.46)、高饱和脂肪酸(OR=1.21,95%CI为1.00~1.47)摄入均增加了子宫内膜癌的发病危险。在亚型分析中,病例对照组合并OR值后亦显示,高总脂肪(OR=1.39,95%CI为1.14~1.70)、高饱和脂肪酸(OR=1.34,95%CI为1.13~1.60)摄入增加了子宫内膜癌的发病危险;在队列研究中未发现总脂肪酸水平与子宫内膜癌发病间具有相关性。在美国(OR=1.39,95%CI为1.00~1.93)的高能量饮食摄入人群(OR=2.17,95%CI为1.57~2.99)和吸烟人群(OR=1.30,95%CI为1.04~1.62)中,饱和脂肪酸高摄入均增加了子宫内膜癌的发病风险。结论:病例对照研究显示,高摄入总脂肪及饱和脂肪酸升高了子宫内膜癌的发病风险。美国的高能量饮食摄入人群及吸烟人群中,饱和脂肪酸高摄入增加子宫内膜癌的发病风险。但尚未发现不饱和脂肪酸与子宫内膜癌发生间存在相关性。仍需纳入更多的流行病学研究,以探讨脂肪摄入与子宫内膜癌间的相关性。
OBJECTIVE: To systematically evaluate the association between fat intake and the risk of developing endometrial cancer. Methods: A computer-based online search of Pub Med, Web of Science, EMbase, CBM, VIP databases and Wanfang databases was conducted to search for epidemiological studies on the correlation between fatty acid intake and the risk of developing endometrial cancer. End of the month. All references were screened and extracted strictly by inclusion and exclusion criteria by two investigators. Stata11.0 software was used for meta-analysis of total fat, saturated fatty acid, polyunsaturated fatty acid and monounsaturated fatty acid respectively. Results: Sixteen studies were finally included, out of a total of 6,480 subjects. The results showed that high total fatty (OR = 1.22, 95% CI 1.02 ~ 1.46) and high saturated fatty acid (OR = 1.21, 95% CI 1.00-1.47) The risk of endometrial cancer. In the subtype analysis, the OR of the case-control group also showed that high total fat (OR = 1.39, 95% CI 1.14-1.70) and high saturated fatty acids (OR 1.34, 95% CI 1.13-1.60) Increased the risk of endometrial cancer risk; in the cohort study found no correlation between total fatty acid levels and the incidence of endometrial cancer. (OR = 2.17, 95% CI, 1.57-2.99) and smokers (OR = 1.30, 95% CI 1.04-1.62) in the United States with high energy intake (OR = 1.39, 95% CI 1.00-1.93) ), High intakes of saturated fatty acids increased the risk of endometrial cancer. CONCLUSIONS: Case-control studies have shown that high intakes of total fat and saturated fatty acids increase the risk of endometrial cancer. High-energy dietary intake in the United States and smokers, high intake of saturated fatty acids increased the risk of endometrial cancer. However, no correlation has yet been found between the occurrence of unsaturated fatty acids and the occurrence of endometrial cancer. More epidemiological studies are still needed to investigate the association between fat intake and endometrial cancer.