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目的探讨胃肠道间质瘤(GIST)的病理特点及免疫组化标记物的表达特征,为其诊断及鉴别诊断提供依据。方法分析40例经手术切除的胃肠道间质瘤患者的临床和病理资料,用免疫组化方法检测细胞表面分化抗原(CD)117、CD34、神经元特异性烯醇化酶(NSE)在胃肠道间质瘤表达的阳性率。结果 CD117阳性率为92.5%,CD34阳性率为77.5%,NSE阳性率为82.5%。30例同时表达CD117和CD34。CD34的表达与部位有关。结论 GIST中的CD117表达敏感性高于CD34,CD117、CD34、NSE联合应用足以明确诊断大多数GIST。根据肿瘤大小、细胞形态、核分裂像及结合免疫组化结果可对GIST危险性进行评估。
Objective To investigate the pathological features of gastrointestinal stromal tumors (GIST) and the expression characteristics of immunohistochemical markers to provide the basis for its diagnosis and differential diagnosis. Methods The clinical and pathological data of 40 patients with surgically resected gastrointestinal stromal tumors were analyzed. The expressions of CD 117, CD34 and NSE were detected by immunohistochemistry in the stomach The positive rate of gut stromal tumors expression. Results The positive rate of CD117 was 92.5%, the positive rate of CD34 was 77.5%, and the positive rate of NSE was 82.5%. 30 cases expressed both CD117 and CD34. CD34 expression and location. Conclusions The sensitivity of CD117 expression in GIST is higher than that of CD34, and CD117, CD34 and NSE are sufficient for the diagnosis of most GISTs. The risk of GIST can be assessed based on tumor size, cell morphology, mitosis, and combined immunohistochemical findings.