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为探讨红霉素抗哮喘气道炎症的机理,对26例过敏性哮喘患者肺泡巨噬细胞(AM),分别加红霉素、地塞米松、生理盐水(空白对照组)培养,测定培养上清液中血栓素B2(TXB2)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)水平。结果显示加红霉素组培养上清液中TNF-α、IL-8水平明显低于空白对照组,TXB2水平与空白对照组无差异;地塞米松组培养上清液中TXB2、TNF-α水平低于空白对照组,IL-8与空白对照组无差异。提示红霉素可通过抑制哮喘患者肺泡巨噬细胞分泌ΤΝF-α、IL-8而起抗炎作用,且其抗炎机理与地塞米松不完全相同。
In order to explore the mechanism of erythromycin in anti-asthmatic airway inflammation, alveolar macrophages (AM) in 26 patients with allergic asthma were respectively cultured with erythromycin, dexamethasone and normal saline (blank control group) Serum TXB2, TNF-α and IL-8 levels were determined. The results showed that the levels of TNF-α and IL-8 in the supernatant of erythromycin group were significantly lower than those in the blank control group, while there was no difference in TXB2 level between the control group and the dexamethasone group. TXB2 and TNF-α The level was lower than the blank control group, IL-8 and the blank control group no difference. It suggested that erythromycin can inhibit the secretion of ΤΝF-α and IL-8 by alveolar macrophages in asthmatic patients, and its anti-inflammatory mechanism is not exactly the same as that of dexamethasone.