论文部分内容阅读
正常成年大鼠肝、肾及心等器官的ATP含量明显高于老年大白鼠,而且肝线粒体氧化还原电位水平也较高.用储血法使大鼠血压降至5.33kPa,形成多器官功能衰竭,肝、肾、心、肺及肠ATP、能荷及肝线粒体氧化还原电位迅速、明显下降并持续在低水平。提示低血流灌注器官的能量代谢迅速受到严重的障碍,使物质代谢和器官功能受阻。低血流灌注后,成年鼠能量代谢的变化比老年鼠更为明显。
The ATP content of liver, kidney and heart in normal adult rats was significantly higher than that of old rats, and the level of redox potential of liver mitochondria was also higher. The blood pressure of rats was reduced to 5.33 kPa by the method of blood storage, resulting in multiple organ failure. ATP, energy load, and liver mitochondrial redox potentials in the liver, kidney, heart, lungs, and intestines rapidly and significantly decreased and persisted at low levels. This suggests that the energy metabolism of low-blood-perfusion organs is rapidly being severely hampered, impeding the metabolism of substances and organ function. After low blood flow, changes in energy metabolism in adult mice are more pronounced than in older mice.