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[目的]研究高原牦牛胎盘粉的抗氧化作用。[方法]将健康小鼠随机分为正常对照组、模型组、阳性对照组、低海拔胎盘组、中海拔胎盘组和高海拔胎盘组,将后5组用D-半乳糖造亚急性衰老小鼠模型;低海拔胎盘组、中海拔胎盘组和高海拔胎盘组的小鼠在建模11 d后每天灌胃牦牛胎盘粉40 mg/只、阳性对照组每天灌服维生素E 100 mg/kg,45 d后观察心、肝、脾、肺、肾组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力和丙二醛(MDA)含量。[结果]高原牦牛胎盘粉可提高小鼠心、肝、脾、肺、肾组织中SOD(P<0.01)和GSH-Px(P<0.01)活力,明显抑制小鼠心、肝、脾、肺、肾组织中MDA(P<0.01)的形成。[结论]高原牦牛胎盘粉有很好的抗衰老作用。
[Objective] To study the antioxidation of placental powder of plateau yak. [Methods] Healthy mice were randomly divided into normal control group, model group, positive control group, low altitude placenta group, middle elevation placenta group and high altitude placenta group, and the latter 5 groups were treated with D-galactose to make subacute aging small Rat models; mice in the low-elevation placenta group, the middle-elevation placenta group, and the high-elevation placenta group were given intragastrically calf placental powder 40 mg/during the 11th day of modeling, and the positive control group was given vitamin E 100 mg/kg daily. After 45 days, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in heart, liver, spleen, lung and kidney tissues were observed. [Result] Plateau yak placental powder could increase the activities of SOD (P<0.01) and GSH-Px (P<0.01) in heart, liver, spleen, lung and kidney of mice, and significantly inhibited the heart, liver, spleen and lung of mice. The formation of MDA (P<0.01) in renal tissue. [Conclusion] Plateau yak placenta powder has good anti-aging effect.