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对１０４例肺癌的血小板表面α－颗粒膜蛋白、血浆血管性假血友病因子、凝血酶原、凝血酶、抗凝血酶Ⅲ进行了测定。结果分别有６６．４％、８１．７％、６２．５％的患者α－颗粒膜蛋白分子数、血管性假血友病因子及凝血酶浓度较正常升高，早晚期差异显著（Ｐ＜０．０５）。９．６％患者抗凝血酶Ⅲ含量和活性减低。追踪观察１．５年发现，有无血栓前状态其转移率和死亡率有显著差异（Ｐ＜０．０５）。由此可见肺癌常伴血栓前状态，其程度与病期及预后密切相关。
The platelet alpha-granule membrane protein, plasma von Willebrand factor, prothrombin, thrombin, and antithrombin III were measured in 104 lung cancer patients. Results There were 66.4%, 81.7%, and 62.5% of patients with α-granule membrane protein molecules, von Willebrand factor, and thrombin concentration, respectively, and they were significantly different in the early and late phases (P< 0.05). Antithrombin III levels and activity were reduced in 9.6% of patients. After 1.5 years of follow-up observation, it was found that there was a significant difference in metastasis rate and death rate before and after thrombosis (P<0.05). This shows that lung cancer often accompanied by pre-thrombotic state, the extent of which is closely related to the stage and prognosis.