ω-氯己醇是有机合成的重要中间体,也是我们最近合成的具有较好抗凝血性能的生物医用高分子材料,聚甲基丙烯酸己磺酸钠(PssHMA)的中间体。ω-氯己醇的合成,按文献报道产率一般在45—50％。我们按文献条件重复,产率一般在40%左右。文献的条件为己二醇与浓盐酸的摩尔比是1:10,反应时间为9小时,用甲苯循环,自然萃取。我们用正交实验法,改进了反应条件,使ω-氯己醇的产率提高到 Omega-chlorohexanol is an important intermediate for organic synthesis and is also an intermediate of our recently synthesized biomedical polymer material with good anticoagulant properties and sodium polymethacrylate (PssHMA). ω-chlorohexanol synthesis, reported in the literature generally yield 45-50%. We repeat the literature conditions, the yield is generally about 40%. The literature conditions for the hexanediol and concentrated hydrochloric acid molar ratio is 1:10, the reaction time is 9 hours, with toluene circulation, natural extraction. We use the orthogonal experiment method to improve the reaction conditions, so that the yield of ω-chlorohexanol to