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目的探讨胃肠道肿瘤术前、术中、术后新辅助治疗对患者术后生存率和肿瘤复发转移的影响。方法回顾性分析20多年来治疗临床研究应用新辅助治疗的理论基础、适应症、毒副反应、联合用药治疗后肿瘤降级、口服化疗药物发展。结果新辅助治疗可提高局部组织和器官的药物浓度、抑制和杀伤大量的敏感肿瘤细胞,减少术中、术后有繁殖活力的肿瘤细胞发生医源性播散、抑制和杀灭微小转移灶。结论新辅助治疗越来越受到重视,并广泛运用到胃肠道肿瘤当中,成为改善患者预后的重要方法之一。
Objective To investigate the effect of neoadjuvant therapy on survival rate and tumor recurrence and metastasis in patients with gastrointestinal cancer before, during and after operation. Methods The theoretical basis, indications, toxic and side effects, neoplasm degradation and oral chemotherapeutics in clinical trials after more than 20 years of treatment were retrospectively analyzed. Results Neoadjuvant therapy can improve the drug concentration in local tissues and organs, inhibit and kill a large number of sensitive tumor cells, reduce iatrogenic dissemination of intraoperative and postoperative proliferative tumor cells, and inhibit and kill micrometastasis. Conclusions Neoadjuvant therapy has drawn more and more attention and is widely used in gastrointestinal cancers, which has become one of the important methods to improve the prognosis of patients.