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目的研究胰岛素样生长因子-Ⅱ(IGF-Ⅱ)与胰岛素样生长因子-Ⅰ受体(IGF-ⅠR)在早期宫颈癌患者中的表达以及临床意义。方法选取宫颈癌患者80例作为观察组,另选取同期因子宫脱垂而实施全子宫切除的患者40例作为对照组。观察两组患者血清中IGF-Ⅱ水平的表达情况,并对比IGF-Ⅱ与IGF-ⅠR在宫颈不同组织中的表达情况,并分析IGF-Ⅱ与IGF-ⅠR在宫颈癌组织中的表达关系。结果观察组患者的血清IGF-Ⅱ的水平以及组织IGF-Ⅱ阳性患者的例数均显著高于对照组。IGF-Ⅱ以及IGF-ⅠR在FIGOⅡ期、鳞癌均显著升高,差异有统计学意义(P<0.05);但组织分级比较差异未见统计学意义。IGF-ⅠR与IGF-Ⅱ在宫颈癌组织的表达中呈正相关(r=0.822,P<0.01)。结论 IGF-Ⅱ与IGF-ⅠR在宫颈癌患者的宫颈组织中普遍存在过表达现象,是对于宫颈癌检测的一项重要的判断指标。
Objective To study the expression and clinical significance of insulin-like growth factor-Ⅱ (IGF-Ⅱ) and insulin-like growth factor-Ⅰ receptor (IGF-ⅠR) in patients with early cervical cancer. Methods Eighty patients with cervical cancer were selected as the observation group. Another 40 patients who underwent hysterectomy due to uterine prolapse during the same period were selected as the control group. The expression of IGF-Ⅱ in serum of two groups of patients was observed, and the expression of IGF-Ⅱ and IGF-ⅠR in different tissues of cervix was compared. The expression of IGF-Ⅱ and IGF-ⅠR in cervical cancer was also analyzed. Results The level of serum IGF-Ⅱ and the number of IGF-Ⅱ positive cases in the observation group were significantly higher than those in the control group. The levels of IGF-Ⅱ and IGF-ⅠR in FIGOⅡ and squamous cell carcinoma were significantly increased (P <0.05), but there was no significant difference in the histological grade. There was a positive correlation between IGF-ⅠR and IGF-Ⅱ in cervical cancer (r = 0.822, P <0.01). Conclusion The overexpression of IGF-Ⅱ and IGF-ⅠR in cervical tissues of patients with cervical cancer is an important indicator for the detection of cervical cancer.