本文的目的是探讨二膦酸化合物抑制牙石的作用。介绍二膦酸化合物,EHDP(1—羟基乙烷—1,1—二膦酸化合物)抑制牙石的机制,动物实验和临床应用。人血清中虽有钙、磷存在,但除牙齿和骨以外的各种组织都不发生钙化现象。这是由于体内的焦磷酸盐(Pyrophosphate)能够抑制磷酸钙结晶沉淀的结果。口腔内环境中的焦磷酸盐浓度比其他体 The purpose of this article is to investigate the effect of bisphosphonates on calculus. The mechanism, animal experiment and clinical application of bisphosphonates and EHDP (1-hydroxyethane-1,1-diphosphonic acid) to inhibit calculus are introduced. Although human serum calcium and phosphorus exist, but in addition to teeth and bones of various tissues are not calcification phenomenon. This is due to the in vivo inhibition of the precipitation of calcium phosphate by the pyrophosphate. The concentration of pyrophosphate in the oral environment is higher than in other bodies