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目的探讨慢性乙型肝炎临床诊断与组织病理学之间的关系。方法将125例乙型肝炎患者肝组织病理标本按炎症活动度分级、纤维化程度分期,比较临床诊断与组织病理学诊断的关系及炎症活动度分级与生物化学指标的关系。结果本组慢性乙型肝炎临床与组织病理学诊断的符合率为76%。伴随肝组织病理学炎症活动度的升高,ALT、AST、TBIL、γ-G的平均值明显升高,而ALB、A/G、PTA值显著下降,差异有统计学意义(P<0.05)。结论慢性乙型肝炎临床诊断与组织病理学诊断的符合率总体不高,可综合分析患者症状、体征,血生化指标,组织病理学检查,以提高诊断准确率。
Objective To explore the relationship between clinical diagnosis and histopathology of chronic hepatitis B. Methods Totally 125 patients with hepatitis B were divided into three groups based on the degree of inflammatory activity, the degree of fibrosis, the relationship between clinical diagnosis and histopathological diagnosis, and the relationship between inflammation activity grade and biochemical indexes. Results The coincidence rate of clinical and histopathological diagnosis of chronic hepatitis B in this group was 76%. With the increase of hepatic histopathological inflammatory activity, the average values of ALT, AST, TBIL and γ-G were significantly increased, while the values of ALB, A / G and PTA were significantly decreased (P <0.05) . Conclusion The coincidence rate of clinical diagnosis and histopathological diagnosis of chronic hepatitis B is generally not high, and the symptoms, signs, blood biochemical indexes and histopathological examination can be comprehensively analyzed to improve the diagnostic accuracy.