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来自食管和胃静脉曲张破裂所致胃肠出血是门脉高压的主要并发病,因此,门脉高压时药物治疗目的将是阻止和预防静脉曲张出血。新近几年研究的各种药物治疗,多数是血管收缩药,目的在于减少进入门脉系统的血流。新近应用血管扩张药治疗,目的是降低门脉系统内血管阻力。理想的门脉高压治疗药应是对肝病病人完全有效,无禁忌症和副作用,不需要复杂装置,能口服,不通过肝代谢或胆道排泄,以免药物影响已存在的肝疾病。
Gastrointestinal hemorrhage due to rupture of the esophagus and gastric varices is a major complication of portal hypertension and therefore the goal of drug therapy in portal hypertension will be to prevent and prevent variceal bleeding. In recent years, various drug treatments, mostly vasoconstrictors, have been studied in order to reduce the blood flow to the portal system. The recent application of vasodilator therapy, the purpose is to reduce portal vascular resistance. The ideal portal hypertension treatment should be completely effective for patients with liver disease, no contraindications and side effects, does not require complicated devices, can be taken orally, without liver metabolism or biliary excretion, so as to avoid drug effects existing liver disease.