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目的探讨中药注射剂不良反应的原因。方法回顾性分析崇左市人民医院2010年1月至2013年1月上报监测中心的42例中药注射剂ADR报告,分别分析患者性别、年龄、临床症状、所涉药品等。重度不良反应者、中度不良反应者应该立即停药,应用抗过敏药物和糖皮质激素,轻度不良反应者未行特殊处理、停药后均自愈。结果 42例中药注射剂ADR涉及12种药品,其中,双黄连注射液发生率最多(26.2%),其次为血栓通注射液(21.4%)、葛根素注射液(11.9%),而发生率最低的为灯盏花注射液、脉络宁注射液、清开灵注射液、复方丹参注射液。32例(76.0%)治愈、10例(23.8%)好转,无死亡病例和后遗症。结论医护人员在临床上应该多注意特殊人群的个体化给药,控制滴注浓度、剂量、速度,避免多药联用,还要对各种中药注射液的适用证、禁忌证予以掌握,以此来保证患者能够安全合理用药。
Objective To explore the causes of adverse reactions of traditional Chinese medicine injection. Methods A retrospective analysis of 42 ADR cases reported by Chongzuo People’s Hospital from January 2010 to January 2013 in the monitoring center was conducted to analyze the patients’ gender, age, clinical symptoms and the drugs involved. Severe adverse reactions, moderate adverse reactions should be discontinued immediately, the application of anti-allergy drugs and glucocorticoid, mild adverse reactions were not special treatment, after stopping all self-healing. Results 42 cases of traditional Chinese medicine injections ADR involved 12 kinds of drugs, of which Shuanghuanglian injection incidence (26.2%), followed by Xueshuantong injection (21.4%), puerarin injection (11.9%), and the lowest incidence Erigeron injection, Mailuoning injection, Qing Kai Ling injection, compound Salvia injection. 32 cases (76.0%) cured, 10 cases (23.8%) improved, no deaths and sequelae. Conclusion Medical staff should pay more attention to the individualized administration of special population in clinic, control the concentration, dosage and speed of drip infusion, avoid multi-drug combination, and also grasp the applicable and contraindications of various traditional Chinese medicine injection This is to ensure that patients can safely and properly medication.