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1964～1996年山东省共发生钩端螺旋体病133371例，有83个疫区县（市，区），占全省县市区的61．48％。病例主要分布在鲁南、鲁东、鲁西南和鲁中地区，以青少年和儿童为多，男女之比为1．6∶1。农村学生和农民发病较多。7～9月份为发病高峰。流行形式主要是雨水型，次为洪水型。流行菌群多是波摩那群。猪是主要传染源。管猪改圈，圈养更新是控制疫情的有效预防措施。
There were 133,371 leptospirosis cases in Shandong Province from 1964 to 1996, with 83 epidemic areas (cities, districts) accounting for 61.48% of the total counties in the province. The cases are mainly distributed in Lunan, Ludong, Southwest Shandong and Central China, with adolescents and children as more male to female ratio of 1.6: 1. More incidence of rural students and farmers. 7 to September peak incidence. The prevailing form is mainly rain type, secondly flood type. Pop groups are mostly Pomona groups. Pig is the main source of infection. Tube pig circle, captive update is an effective preventive measures to control the outbreak.