幽门螺杆菌 (H.pylori)感染与胃癌发生之间存在明显的相关性。其可通过胃粘膜上皮细胞增生与凋亡的失衡 ;激活癌基因和使抑癌基因失活、突变 ;直接或间接影响端粒酶活化等方式 ,使细胞出现肿瘤性转化 ,甚至导致胃癌的发生。但上述致癌机制之间的相互关系尚待进一步研究 There is a clear correlation between H. pylori infection and the occurrence of gastric cancer. It can through the imbalance of gastric epithelial cell proliferation and apoptosis; activation of oncogenes and inactivation of tumor suppressor genes, mutations; direct or indirect effects on telomerase activation and other ways, so that the cells appear tumorous transformation, and even lead to the occurrence of gastric cancer . However, the relationship between the above carcinogenic mechanisms needs further study.