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目的评价加巴喷丁对慢性偏头痛发作预防的有效性和安全性。方法共入组顽固性偏头痛病例60例。其中加巴喷丁组、吲哚美辛组治疗各30例。治疗前2组的一般资料、临床评价和实验室指标无统计学差异。结果治疗第1周,加巴喷丁组和吲哚美辛组头痛消失率分别为(76±5)%和(42±6)%(P<0.01);加巴喷丁组头痛缓解率(13±3)%,吲哚美辛组头痛缓解率(8±2)%(P>0.05),治疗第三周加巴喷丁组和吲哚美辛组头痛消失率分别为(89±6)%和(50±7)%(P<0.01);加巴喷丁组头痛缓解率(10±2)%和(12±3)%(P>0.05),加巴喷丁治疗中,有2例患者出现头晕,失眠,无肝、肾功能等影响。结论加巴喷丁治疗慢性阵发性偏侧头痛安全性好,可以作为预防控制慢性偏侧头痛的有效药物。
Objective To evaluate the efficacy and safety of gabapentin in the prevention of chronic migraine attacks. Methods A total of 60 cases of intractable migraine were included. Among them, gabapentin group and indomethacin group were given 30 cases each. General information before treatment 2 groups, clinical evaluation and laboratory indicators no significant difference. Results The headache disappearance rates in the gabapentin group and indomethacin group were (76 ± 5)% and (42 ± 6)%, respectively (P <0.01) at the first week of treatment. The headache relief rate was (13 ± 3)% in the gabapentin group, The headache relief rate was (8 ± 2)% in indomethacin group (89 ± 6)% and (50 ± 7)% respectively in gabapentin group and indomethacin group during the third week of treatment (P <0.01). The headache relief rate was (10 ± 2)% and (12 ± 3)% in gabapentin group, and dizziness, insomnia, liver function and renal function in gabapentin group . Conclusion Gabapentin in the treatment of chronic paroxysmal partial headache is safe and can be used as an effective drug for the prevention and control of chronic side-headed headache.