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急性胰腺炎已被认为是临床一大问题,死亡率极高。其基本病机是由于蛋白分解酶引起的自我消化。所以一个合乎逻辑的设想,是找到一个方法暂时抑制胰腺分泌的合成和分解。细胞内蛋白质的合成是由去氧核糖核酸(DNA)和核糖核酸(RNA)所控制,蛋白质的合成直接关系到细胞内RNA的含量。胰腺腺泡的RNA是丰富的,并可产生丰富蛋白质的胰腺液。经证实,5—FU能引起正常胰腺细胞质含量的暂时性减少,同时
Acute pancreatitis has been considered a major clinical problem, the mortality rate is extremely high. The basic pathogenesis is due to proteolytic enzymes caused by self-digestion. So a logical idea is to find a way to temporarily inhibit pancreatic secretion of synthesis and decomposition. The synthesis of intracellular proteins is controlled by DNA and RNA, which are directly related to intracellular RNA content. Pancreatic acinar RNA is abundant and produces abundant protein in pancreatic fluid. It has been confirmed that 5-FU can cause a temporary reduction in the normal pancreatic cytoplasm content, at the same time