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鼻内应用Flunisol ide治疗变应性鼻炎效果是肯定的。本文目的是研究其治疗效果是由于局部作用抑或全身作用。与鼻内应用Flunisolide100μg相当的口服生物等值量为500μg。作者于1983年豚草花粉症季节进行了比较研究,采用多中心、随机、双盲安慰剂对照研究。共99例患者,病程至少2年,豚草花粉浸液点刺试验呈阳性反应。随机分为三组:O组33例,口服500μg,鼻内应用安慰剂,均为每天两次。N组31例,每侧鼻腔
Nasal use Flunisol ide treatment of allergic rhinitis effect is yes. The purpose of this paper is to investigate whether the therapeutic effect is due to local or systemic effects. The oral bioequivalence equivalent to 100 μg of Flunisolide administered intranasally was 500 μg. The authors compared the ragweed season in 1983 with a multicenter, randomized, double-blind, placebo-controlled study. A total of 99 patients, duration of at least 2 years, ragweed pollen infusion prick test was positive. Randomly divided into three groups: O group 33 cases, oral 500μg, intranasal placebo, are twice a day. N group of 31 cases, each side of the nasal cavity