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背景和目的:阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与心血管不良事件相关,其中包括心肌梗死和卒中。动脉硬化是导致这些心血管事件的主要机制。最近的横断面研究结果显示,没有合并症的 OSAHS 患者也存在动脉硬化的早期表现。因此,本研究观察了持续气道内正压(CPAP)治疗对动脉硬化的影响。为了验证 OSAHS 直接参与动脉硬化的假说,本研究只纳入没有合并症的重度OSAHS 患者。方法:在为期2年的时间内对400例男性重度OSAHS 患者进行了筛选,其中376例因合并高血压、糖尿病、心力衰竭、冠心病、卒中、吸烟、长期服药、拒绝入组或其
Background and Objectives Obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with cardiovascular events, including myocardial infarction and stroke. Arteriosclerosis is the primary mechanism responsible for these cardiovascular events. Recent cross-sectional studies have shown early signs of arteriosclerosis in OSAHS without comorbidities. Therefore, we examined the effects of continuous positive airway pressure (CPAP) on arteriosclerosis. To verify the hypothesis that OSAHS is directly involved in atherosclerosis, this study included only patients with severe OSAHS without comorbidity. Methods: Four hundred male patients with severe OSAHS were screened over a 2-year period, of which 376 were rejected because of hypertension, diabetes mellitus, heart failure, coronary heart disease, stroke, smoking, long-term medication,