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利用烯类单体通过接枝共聚将纤维素功能化。在1-烯丙基-3-甲基氯代咪唑(AMIMCl)离子液体中,纤维素和简单的有机卤化物通过氧化还原反应合成了大分子引发剂纤维素2-溴丙酸酯,利用原子转移自由基聚合(ATRP)法接枝共聚合成了纤维素接枝聚甲基丙烯酸甲酯材料(cellulose-g-PMMA),从而实现活性种与休眠种之间的可逆动态平衡。并且通过核磁共振(NMR)、傅立叶变换红外光谱(FTIR)以及透射电子显微镜(TEM)等测试,对该材料进行了物理检测。利用白桦脂酸作为模型药物,并采用纳米沉淀法成功制备了纤维素/白桦脂酸纳米药物,并对其缓释性能及释放进行了探讨。结果表明:cellulose-g-PMMA具有作为缓释药物载体的潜力。
Cellulose is functionalized by grafting copolymerization with ethylenic monomers. In 1-allyl-3-methylimidazolium chloride (AMIMCl) ionic liquid, cellulose and simple organic halide were synthesized by redox reaction of macromolecular initiator cellulose 2-bromopropionate, the use of atoms Cellulose grafted polymethylmethacrylate (cellulose-g-PMMA) was graft copolymerized by transfer radical polymerization (ATRP) to achieve a reversible dynamic equilibrium between the active species and dormant species. The material was physically detected by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). Betulinic acid was used as a model drug and cellulose / betulinic acid nano-drug was successfully prepared by nano-precipitation method. The sustained-release properties and release of the drug were also discussed. The results showed that cellulose-g-PMMA has the potential of being a sustained-release drug carrier.