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本文采用激素、免疫抑制剂、中药联合治疗狼疮性肾炎(LN)32例(女30例,男2例);年龄15～56岁,按1982年美国风湿病学会修订的SLE诊断标准确立诊断。1.热毒炽盛型;2.脾肾阳虚型;3.阴虚内热型;4.肝肾阴虚型。以上各型在病程中可互相转化。治疗:1.激素:强的松每日清晨顿服1mg/kg,8周后,每周减量5mg,到维持量(隔日0.4mg/kg)。重症LN宜先用激素冲击疗法,后改为强的松口服。2.环磷酰胺8～12mg/kg加入生理盐水100ml内静脉注射,静注时间不少于1小时,连用2天,每2周1次,累积总剂量≤150mg/kg。在维持治疗阶段,如有狼疮活动
Thirty-two women (30 males and 2 men) with lupus nephritis (LN) were treated with hormones, immunosuppressants and Chinese herbs. Patients aged 15-56 years old were diagnosed according to the diagnostic criteria of SLE revised by American College of Rheumatology in 1982. 1. Toxic heat flaming type; 2. Spleen and kidney yang; 3. Yin heat type; 4. Liver and kidney type. The above types in the course of disease can be transformed into each other. Treatment: 1. Hormones: prednisone daily morning wear Dayton 1mg / kg, 8 weeks after the weekly reduction of 5mg, to maintain the amount of (0.4mg / kg the next day). Severe LN should be the first hormone therapy, later changed to prednisone oral. 2. Cyclophosphamide 8 ~ 12mg / kg added saline 100ml intravenous injection, intravenous injection time of not less than 1 hour, once every 2 days, once every 2 weeks, the cumulative total dose ≤ 150mg / kg. In the maintenance phase, if lupus activity