论文部分内容阅读
为探讨急性肝炎、肝硬化中ＮＯ和ＴＮＦ变化的意义，测定了２５例急性肝炎和３５例肝硬化病人与３０例正常人血清中的ＮＯ和ＴＮＦα水平。结果显示：与正常人比较，急性肝炎患者血清ＮＯ水平无明显增高（Ｐ＞００５）；而ＴＮＦα水平明显增高（Ｐ＜００１），但较肝硬化为低（Ｐ＜００１）。肝硬化患者，ＮＯ和ＴＮＦα均显著增高（Ｐ＜００１）。提示：尽管ＮＯ不参予急性肝炎患者的肝细胞损伤，但ＮＯ和ＴＮＦα却能加剧肝硬化患者的病理生理学紊乱。
In order to explore the significance of the changes of NO and TNF in acute hepatitis and cirrhosis, the levels of NO and TNFα in serum of 25 patients with acute hepatitis, 35 patients with cirrhosis and 30 normal persons were determined. The results showed that compared with normal subjects, serum NO levels in patients with acute hepatitis were not significantly increased (P> 005), but TNFα levels were significantly higher (P <001), but lower than those in patients with cirrhosis ). In cirrhotic patients, NO and TNFα were significantly higher (P <001). Tip: Although NO is not involved in hepatocellular injury in patients with acute hepatitis, NO and TNFα exacerbate the pathophysiology of cirrhosis.