探讨双侧原发性乳腺癌(BPBC)的临床病理特征。方法收集13例BPBC的临床病理资料,观察和分析其临床病理特征并随访。结果 13例BPBC均为女性,其中同时性BPBC 4例,异时性BPBC 9例。BPBC首发癌与次发癌的ER、PR、Her-2的表达较一致。13例均获随访,其中3例死亡,10例存活,存活时间为4~78个月。结论正确积极治疗BPBC,其5年生存率与单侧乳腺癌相同。首发癌后5年是预防的重点。 To investigate the clinicopathological features of bilateral primary breast cancer (BPBC). Methods Clinicopathological data of 13 cases of BPBC were collected, their clinical and pathological features were observed and analyzed. Results All the 13 cases of BPBC were female, including 4 cases of simultaneous BPBC and 9 cases of abnormal BPBC. The expressions of ER, PR and Her-2 in BPBC primary and secondary cancers were more consistent. Thirteen patients were followed up, 3 of them died, 10 survived and the survival time was 4 to 78 months. Conclusion Correct and correct treatment of BPBC, its 5-year survival rate and unilateral breast cancer the same. Five years after the first cancer is the focus of prevention.