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目的探讨胰岛素治疗口服降糖药失效2型糖尿病的临床效果。方法选择2013年1月—2014年7月来该院进行治疗的口服降糖药失效2型糖尿病患者68例为研究对象,将所有患者随机分为对照组(诺和灵30R)和观察组(诺和锐30),比较治疗前后两组患者的空腹血糖(FPG)、2 h餐后血糖(2 h PG)、糖化血红蛋白(Hb A1c)及治疗后低血糖的发生情况、患者对降糖效果的满意程度。结果治疗后患者的FPG、2 h PG及Hb A1c水平明显低于治疗前;治疗后观察组患者的FPG、2 h PG及Hb A1c水平与对照组无明显差异(P>0.05);但观察组低血糖的发生情况及严重程度明显少于对照组,满意度明显高于对照组,差异有统计学意义(P<0.05)。结论在口服降糖药失效的2型糖尿病的治疗上,诺和灵30R与诺和锐30的临床疗效相似,但诺和锐30低血糖发生率更低,严重低血糖事件更少,值得在临床上进一步推广应用。
Objective To investigate the clinical effect of insulin therapy on type 2 diabetes patients with oral hypoglycemic agents failure. Methods Sixty-eight patients with type 2 diabetes mellitus who were treated with oral hypoglycemic agents from January 2013 to July 2014 in our hospital were selected as study subjects, and all patients were randomly divided into control group (Novolin 30R) and observation group ( Novo Rui 30). The levels of fasting blood glucose (FPG), 2h postprandial blood glucose (2h PG), Hb A1c and post-treatment hypoglycemia in both groups were compared before and after treatment. The patients’ hypoglycemic effect Satisfaction. Results The levels of FPG, 2 h PG and Hb A1c in patients after treatment were significantly lower than those before treatment. The levels of FPG, 2 h PG and Hb A1c in the observation group were not significantly different from those in the control group (P> 0.05) The incidence and severity of hypoglycemia were significantly less than those in the control group, and the satisfaction was significantly higher than that in the control group (P <0.05). Conclusions In the treatment of type 2 diabetes with oral hypoglycemic agents, the clinical effects of Novolin 30R and NovoRui 30 are similar, but the incidence of hypoglycemia in NovoRui 30 is lower and less severe hypoglycemic events are worth Clinically further promotion and application.