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研究系统性红斑狼疮 (SLE)性肝损害的发生率、临床表现及免疫学特点。方法 :对符合SLE诊断的5 2 0例病人的肝损害进行回顾性调查分析。结果 :5 2 0例病人中狼疮性肝损害者有 32例 (6 .1% ) ,其中 75 %病人无肝损害的临床症状 ,主要表现为轻、中度的转氨酶升高 ,4例出现黄疸 ;狼疮性肝损者血清抗核糖体P蛋白抗体 (抗Rib -P)阳性率显著高于无肝损者 ,而ANA、抗Sm抗体、抗dsDNA抗体等自身抗体阳性率两者无差异 ;有肝损者关节炎、脑损害的发生率高于无肝损者。结论 :系统性红斑狼疮本身所致的肝损害发生率并不低 ,临床上大多表现为轻、中度的肝功能异常 ,有小部分临床症状较重。抗Rib -P与狼疮性肝损害关系密切 ,可能与狼疮性肝损害发生有关。
To study the incidence, clinical manifestations and immunological characteristics of systemic lupus erythematosus (SLE) liver damage. Methods: Retrospective analysis was performed on liver damage in 520 patients who were diagnosed as SLE. Results: Of the 520 patients, 32 (6.1%) had lupus-like liver damage, of which 75% had no clinical signs of liver damage. The main symptoms were mild to moderate elevated aminotransferases and 4 cases of jaundice ; The positive rate of serum anti-ribosomal P protein antibody (anti-Rib-P) in patients with lupus liver disease was significantly higher than those without liver damage, while there was no difference in the positive rate of autoantibodies such as ANA, anti-Sm antibody and anti-dsDNA antibody; Arthritis with liver damage, the incidence of brain damage than those without liver damage. Conclusion: The incidence of liver damage caused by systemic lupus erythematosus itself is not low. Most of the clinical manifestations are mild to moderate liver dysfunction with a small number of severe clinical symptoms. Anti-Rib-P and lupus liver damage are closely related, may be related to the occurrence of lupus liver damage.