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目的探讨化脓性脑膜炎患儿脑脊液丙二醛和一氧化氮水平变化及临床意义。方法化脓性脑膜炎患儿51例为观察组(重症组21例,轻症组30例),非化脓性脑膜炎患儿40例为对照组,采用比色法测定观察组急性期和恢复期脑脊液丙二醛和一氧化氮水平,并与对照组进行比较。结果观察组急性期脑脊液丙二醛含量为(5.79±1.33)μmol/L,一氧化氮为(16.36±3.84)μmol/L,与恢复期((2.85±0.64)μmol/L,(8.31±1.99)μmol/L)和对照组((2.52±0.32)μmol/L,(7.27±1.06)μmol/L)比较差异有统计学意义(P<0.05);急性期重症组丙二醛((7.02±0.86)μmol/L)和一氧化氮((19.90±2.64)μmol/L)水平高于轻症组((4.94±0.84)μmol/L,(13.87±2.26)μmol/L)(P<0.05),轻症组高于对照组(P<0.05)。结论丙二醛和一氧化氮参与了化脓性脑膜炎的病理过程,可作为化脓性脑膜炎病情发展及严重程度的判定指标。
Objective To investigate the changes of cerebrospinal fluid malondialdehyde (MDA) and nitric oxide (NO) in children with purulent meningitis and its clinical significance. Methods 51 cases of purulent meningitis in the observation group (21 cases of severe group, 30 cases of mild group), 40 cases of non-purulent meningitis in the control group, the determination of the observation group by acute phase and convalescence Cerebrospinal fluid malondialdehyde and nitric oxide levels, and compared with the control group. Results The levels of malondialdehyde in cerebrospinal fluid in the observation group were (5.79 ± 1.33) μmol / L and (16.36 ± 3.84) μmol / L, respectively, and were significantly higher than those in the recovery group (2.85 ± 0.64 μmol / L, 8.31 ± 1.99 (P <0.05). In the severe acute group, malondialdehyde ((7.02 ±) μmol / L) and the control group (2.52 ± 0.32 μmol / L, (4.94 ± 0.84) μmol / L, (13.87 ± 2.26) μmol / L) were significantly higher than those in mild group (P <0.05) , Mild group than the control group (P <0.05). Conclusions Malondialdehyde and nitric oxide are involved in the pathological process of purulent meningitis, which can be used as the evaluation index of the severity and development of purulent meningitis.