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[目的]评价综合治疗对中晚期宫颈鳞癌细胞增殖及血管生成的影响。[方法]43例ⅡB～ⅢB期宫颈鳞癌进行综合治疗(术前动脉插管化疗+放疗和/或静脉化疗),免疫组化SABC法检测治疗前后宫颈鳞癌组织中Ki67和VEGF表达。[结果]综合治疗后手术率为81.4%(35/43);治疗前后宫颈鳞癌组织中Ki67阳性表达率分别为65.12%、28.57%(P<0.01),VEGF阳性表达率分别为88.37%、51.43%(P<0.01)。术后复发组中Ki67和VEGF阳性表达率均显著性高于未复发组。[结论]综合治疗能抑制宫颈癌肿瘤细胞增殖和血管生成,提高手术概率。术后Ki67和VEGF高表达者更易复发。
[Objective] To evaluate the effect of comprehensive treatment on the proliferation and angiogenesis of advanced cervical squamous cell carcinoma. [Method] Forty-three patients with cervical squamous cell carcinoma of stage ⅡB ~ ⅢB underwent preoperative arterial catheterization combined with radiotherapy and / or intravenous chemotherapy. The expression of Ki67 and VEGF in cervical squamous cell carcinoma tissue was detected by immunohistochemical SABC method. [Results] The operative rate was 81.4% (35/43) after treatment. The positive rates of Ki67 in cervical squamous cell carcinoma before and after treatment were 65.12%, 28.57% (P <0.01), respectively. The positive rates of VEGF were 88.37% 51.43% (P <0.01). The positive rates of Ki67 and VEGF in postoperative recurrence group were significantly higher than those in non recurrence group. [Conclusion] The comprehensive treatment can inhibit the proliferation of cervical cancer cells and angiogenesis, improve the probability of surgery. Postoperative Ki67 and VEGF are more likely to relapse.