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胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)是一种主要由皮肤、肺、胸腺与胃肠道等器官的上皮细胞分泌的与IL-7类似的炎性细胞因子。TSLP是一种多功能的细胞因子,可以作用于多种细胞如T细胞、B细胞、DC和肿瘤细胞等,具有重要的生物学功能。近年来,越来越多的研究表明,TSLP能够调控肿瘤的发生发展。一方面,TSLP在结肠癌、皮肤癌以及初期乳腺癌、胰腺癌的发展阶段发挥了重要的抗肿瘤作用;另一方面,TSLP在胃癌、肺癌、子宫颈癌和急性淋巴细胞白血病等恶性肿瘤的发生发展过程中发挥促进肿瘤进展的作用,提示TSLP可作为相关肿瘤治疗的潜在靶点。本文综述了近年来TSLP及其信号通路,以及其与乳腺癌、胰腺癌、子宫颈癌、胃癌、结肠癌、肺癌、皮肤癌、B细胞急性淋巴细胞白血病等多种恶性肿瘤发生发展的关系的研究进展,旨在为相关肿瘤的诊断和治疗提供新的思路。
Thymic stromal lymphopoietin (TSLP) is an IL-7-like inflammatory cytokine secreted by epithelial cells of the skin, lung, thymus and gastrointestinal tract. TSLP is a multifunctional cytokine that has important biological functions in a wide range of cells such as T cells, B cells, DCs and tumor cells. In recent years, more and more studies have shown that TSLP can regulate the occurrence and development of tumors. On the one hand, TSLP plays an important antitumor role in the development of colon cancer, skin cancer, as well as primary breast cancer and pancreatic cancer. On the other hand, TSLP plays an important antitumor role in the carcinogenesis of gastric cancer, lung cancer, cervical cancer and acute lymphoblastic leukemia Play a role in promoting tumor progression in the development process, suggesting that TSLP can be used as a potential target for the treatment of cancer. This review summarizes the recent advances in TSLP and its signaling pathways and their relationship with the development of various malignancies such as breast, pancreatic, cervical, gastric, colon, lung, skin, B cell acute lymphoblastic leukemia Research progress, aimed at the diagnosis and treatment of related tumors provide new ideas.