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胰岛素抵抗是机体对正常剂量胰岛素的生理反应敏感性减弱,导致机体葡萄糖摄取和利用的效率下降,因此为了维持血糖的稳定,机体自发代偿性的分泌过多胰岛素从而产生高胰岛素血症参与运动是改善IR、治疗糖尿病、高血压等慢性疾病的重要手段之一。肝脏作为糖类代谢的重要靶器官,在胰岛素抵抗中占有重要地位,而运动疗法旨在提高靶组织对胰岛素的敏感性、改善糖脂代谢、促进胰岛素信号途径转导方面实现治疗胰岛素抵抗的目的。
Insulin resistance is the body’s sensitivity to normal physiological changes in insulin sensitivity weakened, leading to the body’s efficiency of glucose uptake and utilization decreased, so in order to maintain the stability of blood glucose, the body spontaneously compensatory secretion of excess insulin to produce hyperinsulinemia involved in exercise Is to improve IR, diabetes, hypertension and other chronic diseases one of the important means. Liver as an important target organ of carbohydrate metabolism, plays an important role in insulin resistance, while exercise therapy aims to improve the sensitivity of target tissues to insulin, improve glucose and lipid metabolism, and promote insulin signaling transduction aspects of the purpose of the treatment of insulin resistance .