在变态反应学术会议上提出的第二项成就是对具有青霉素过敏反应的病人采用4小时的脱敏疗法。用这种方法,病人即可应用常规足量的β-内酰胺抗生素,而不会发生严重的过敏反应。德克萨斯州西北医学院的Sullivan博士说,这种新方法的唯一特点是采用青霉素口服脱敏法。Sullivan等试验的对象仅限于这样一类病人,这些病人得了致命的感染,但青霉素应试阳性或对青霉素有过敏反应,而其它抗生素对这些感染又无效。口服脱敏法的步骤是:开始,给病人100单位的青霉素口服,以后每隔15分钟给予加倍的剂量,等剂量到达40万单位为止。然后给20万单位进行皮下注射,15分钟后再注射4倍的剂量。这样,在这个基础上,即可应 The second achievement presented at the allergy conference was a 4-hour desensitization of patients with allergic reactions to penicillin. In this way, the patient can use the usual amount of beta-lactam antibiotics without serious allergic reactions. Dr. Sullivan of Northwestern Medical School in Texas says the only feature of this new approach is the penicillin oral desensitization method. Sullivan and other trials were limited to patients who had a fatal infection but were either tested positive for penicillin or allergic to penicillin and none of the other antibiotics were effective against these infections. The procedure for oral desensitization is as follows: Beginning, 100 units of penicillin are given orally to the patient, doubling the dosage thereafter every 15 minutes until the equivalent dose reaches 400,000 units. 200,000 units were then subcutaneously injected, followed by a four-fold dose 15 minutes later. In this way, on this basis, we can do it