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目的探讨HIV感染艾滋病期患者口咽部假膜型念珠菌病(POC)可能的危险因素。方法选取HIV感染发展至艾滋病期患者234例,其中合并POC 116例(A组),未合并POC 118例(B组)。回顾性分析HIV感染艾滋病期并发或不并发POC患者入院时HIV发现的间隔时间、淋巴细胞、CD3+T细胞、CD4+T细胞、CD8+T细胞计数等指标的情况。结果 234例中,A组淋巴细胞、CD4+T细胞、CD8+T细胞表达水平低于B组(P<0.05)。根据受试者工作特征曲线的最佳预测值进行单因素、多因素分析。淋巴细胞计数为混杂因素(P>0.05);CD4+T细胞、CD8+T细胞计数以及发现HIV感染至入组时间与POC发生有关(P>0.05)。结论在HIV感染进入艾滋病期患者中,CD4+T细胞≤44.15个/μl、CD8+T细胞≤324.7个/μl、发现HIV感染至入组时间≤3.5个月是预测POC发生的较好指标。
Objective To explore the possible risk factors of pseudopharax candidiasis (POC) in the oropharynx of HIV-infected patients. Methods A total of 234 patients with HIV infection developed to AIDS were enrolled. Among them, 116 cases were complicated with POC (group A) and 118 cases were not combined with POC (group B). Retrospective analysis of AIDS HIV infection in patients with or without concurrent POC admission to HIV at the time of discovery, lymphocytes, CD3 T cells, CD4 T cells, CD8 T cell count and other indicators. Results Among 234 cases, the expression of lymphocyte, CD4 + T cell and CD8 + T cell in group A was lower than that in group B (P <0.05). Univariate and multivariate analyzes were performed based on the best predictors of subjects’ performance curves. Lymphocyte counts were confounding factors (P> 0.05). The count of CD4 + T cells and CD8 + T cells and the time from finding HIV infection to infiltration were related to the occurrence of POC (P> 0.05). Conclusion CD4 + T cells ≤44.15 cells / μl and CD8 + T cells ≤324.7 cells / μl in the HIV-infected patients. It was found that the HIV infection was less than 3.5 months and the prognosis of POC was better.